| Induffden | Date: Tuesday, 02 Apr 2013, 5:30 PM | Message # 1 |
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Nitrofurantoin is excreted into breast milk. in one study, the drug could not be detected in 20 samples from mothers receiving 100 mg 4 times daily (12). in a second study, nine mothers were given 100 mg every 6 hours for 1 day, then either 100 mg or 200 mg the next morning (13). only two of the four patients receiving the 200-mg dose excreted measurable amounts of nitrofurantoin, 0.3–0.5 µg/ml. although these amounts are negligible, the authors cautioned that infants with g-6-pd deficiency may develop hemolytic anemia from this exposure (13).
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To reduce the development of drug-resistant bacteria and maintain the effectiveness of duricef (cefadroxil) and other antibacterial drugs, duricef (cefadroxil) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. when culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. in the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
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